Comparison between transmural and non-transmural infarction and the area at risk using T2 weighted imaging

Methods The study population consisted of 20 patients with acute ST-elevation myocardial infarction treated by primary PCI. Cardiac MRI was performed within 10 days. The infarct size and the transmural extent of infarction (TEI) and mean TEI was quantified on delayed-enhancement images using 36 segments for each slices. AAR was quantified on T2-weighted images. Transmural infarction was defined as mean TEI>75%. The salvage border was defined as number of segments in AAR without any late enhancement and infarct salvage as AAR minus area with late enhancement. End-diastolic wall thickness (EDWT), segmental wall thickening (SWT) were quantified on cine-images. Myocardial function was calculated in the AAR and included the infarct, peri infarct, salvage border and was compared to remote myocardium Results Infarct mass was 38±23 gram, infarct size was 25±13% of the left ventricle. AAR mass was 70±30 gr, AAR size was 42±15% of the left ventricle. The salvage myocardium was 46±16% of the AAR. Mean TEI was 70±15%. Salvage size is increased in the non-transmural infarct compared to non-transmural infarction (20±7 to 13±7%, p=.02). There was no significant difference in the salvage border between non-transmural and transmural infarction (18±14 and 14±9 gram, p=.43) although the total infarct salvage was increased in the non-transmural infarction (18±10 to 10 ±5 gram, p=.04). EDWT was increased in AAR compared to the remote myocardium (6.9±0.9 to 6.0±1.0 mm, p=.01), with no difference within the AAR. SWT was impaired in the AAR compared tot the remote (28±17% and 66±18%, p<.01). Within the AAR the SWT was significantly increased in the infarct compared to the salvage myocardium (ANOVA, p<.01).